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Targeted Protein Degradation: The Power of PROTACs

Could hijacking one of the body’s own systems be the key to finding new targets for hard-to-treat diseases? Dane Mohl, Ph.D., scientist at Amgen (Thousand Oaks, CA) believes it may be. With the advent of genomics, drug development has focused on using genetics to identify therapeutic targets, which has led to targets that aren’t necessarily easily drugged through traditional methods. “Letting genetics guide our choices for treating disease means we have to use whatever modalities are available,” Mohl says. “We have to be more creative and that means we need a larger tool box to get to those new targets.”


Thanks for a Great Year!

By Sabeth Verpoorte, Ph.D.

It seems like just yesterday that I assumed the SLAS presidency at SLAS2018, last February in San Diego, and now the year is almost up! It’s time for me to say farewell and hand over the reins to my successor, Alan E. Fletcher, Ph.D., of PerkinElmer Discovery and Analytical Solutions (Hopkinton, MA, USA). I’ve really enjoyed my three years on the SLAS Board of Directors and am honored to have been given the opportunity to serve as the Society’s 2018 president.


Meet SLAS Scientific Director Mike Tarselli

Take a little wonder and the desire to do good. Throw in meaningful research experience, honest commitment, science smarts and a whole lot of energy, and you've taken one step toward describing SLAS's Scientific Director Michael (Mike) Tarselli, Ph.D. The Boston (MA, USA) native started his position with the Society in September of 2018, and finds his new role yet another way to make life better for scientists, engineers and the world.