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DNA-Encoded Library Technology: A Quarter Century of Progress

“DELT [DNA-Encoded Library Technology] provides an economical and feasible means to make progress toward the exploration of larger chemical spaces. Instead of a focusing on one to two million compounds in a typical high-throughput screen (HTS), a DELT library may present some hundred million compounds for selection by a biological target of interest. The concepts of drug-likeness, chemical diversity and compound collection are still important, but the efficiency of the DELT process shifts the balance of opportunity costs in a unique manner relative to the traditional HTS compound collection and process.” – Robert Goodnow, Ph.D., SLAS Discovery Guest Editor


Lineage Sequencing: A Novel Approach to Mutation Analysis

“Biological processes are dynamic; they require dynamic measurements to understand them,” says Yehuda Brody, Ph.D. Brody, a third-year post-doctoral associate in the Blainey Lab at the Broad Institute of MIT and Harvard (Cambridge, MA) who has been visually measuring single cell gene expression kinetics for several years. Now, focusing on mutagenesis process kinetics, he and his colleagues have developed a new method for DNA sequencing that allow them to analyze the flow of mutation accumulation with single cell cycle resolution. Paul Blainey, Ph.D., presented this innovative approach at SLAS2018.


Mathias Uhlén: Discovering the Building Blocks of Man

Researcher Mathias Uhlén, Ph.D., opens the human proteome for all researchers to explore. He then leads the journey into what makes us healthy, how disease starts, when the aging process begins and how to apply that knowledge to life sciences discovery and technology to improve the human condition.