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Editorial Archive

August 13, 2018
Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development
Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

What if there was a more efficient way to select safer drugs to move into clinical development while reducing attrition? How much time and money could be saved and how much energy could be refocused on enabling safe drugs that address unmet medical needs to reach patients more quickly? Clinical Trials in a Dish (CTiD) studies are poised to revolutionize thinking about practical, immediate and near-term applications in the field of drug discovery and development.

August 6, 2018
Innovative Technology Accelerates Cell-Based Therapies
Innovative Technology Accelerates Cell-Based Therapies

The rapid expansion of T-cell and other cell-based therapies has ignited discussions about how clinicians and researchers harvest, culture, process or directly alter therapeutic cells. The guest editors of a new SLAS Technology Special Issue delve into innovative tools that improve the process by scaling up manufacturing, reducing costs and improving safety.

July 30, 2018
Even More at Home with SLAS...
Even More at Home with SLAS...

By Sabeth Verpoorte, Ph.D.

I really enjoyed the 2018 SLAS Europe Conference and Exhibition held last month in Brussels, Belgium. It was a resounding success in my eyes – both from my perspective as Society president and as a participant seeking educational value. SLAS CEO Vicki Loise provided some organizational detail in her blog post, “It’s a Wrap! First SLAS Europe Conference and Exhibition is a Success,” so I’ll focus on its value to me as a participant.

July 23, 2018
High-Powered Multiplexing with Flow Cytometry in High-Throughput Systems
High-Powered Multiplexing with Flow Cytometry in High-Throughput Systems

The August 2018 SLAS Discovery Special Issue on High-Throughput Flow Cytometry in Drug Discovery captures recent advances that inform us about the current state of automated workflows, the expanding range of applications and the creativity in some novel assays. The issue is timely as “high-throughput flow cytometry (HTFC) is gaining acceptance and people are using it in innovative ways,” says Co-Guest Editor Bruce Edwards, Ph.D., of the University of New Mexico (UNM, Albuquerque, NM, USA).

July 9, 2018
2018 SLAS Graduate Education Fellowship Grant Recipient Fosters SERS Diagnostic Assay Concept
2018 SLAS Graduate Education Fellowship Grant Recipient Fosters SERS Diagnostic Assay Concept

Using surface-enhanced Raman spectroscopy (SERS) to uncover the mysteries of circulating tumor DNA in the bloodstream, an innovative Ph.D. candidate from Johns Hopkins University encourages others to bravely tackle research problems outside their areas of expertise. “You can apply what you know already to answer questions in life sciences.”

June 25, 2018
Volunteer Expertise, Ideas and Energy
Volunteer Expertise, Ideas and Energy

By Sabeth Verpoorte, Ph.D.

Earlier this year, I expressed my appreciation of the many SLAS volunteers and the countless hours committed to this Society. As I move deeper into my presidency, it becomes clearer to me that SLAS would not exist without volunteer dedication to the Society. Our volunteers are SLAS!

June 14, 2018
At the Intersection of Discovery and Technology: Understanding Inflammation in the SLAS Zone
At the Intersection of Discovery and Technology: Understanding Inflammation in the SLAS Zone

Daniel Irimia, M.D., Ph.D., is an engineer at heart. However, he took a slight detour en route to his current role as associate professor and deputy director of the BioMEMS Resource Center at the Center for Engineering in Medicine, Massachusetts General Hospital (Boston, MA) after first training as a medical doctor in his native Romania. Now combining an engineer’s mind with a physician’s knowledge, he and his colleagues have designed a large-scale microparticle-cluster array to replicate human neutrophil swarming outside the body, which allows the study of signaling pathways and mediators during swarming.

June 4, 2018
Celebrating Statistical Guidance and Integration in Biomedical Science
Celebrating Statistical Guidance and Integration in Biomedical Science

“When biostatisticians and biomedical scientists work together – early and often – the end result is more satisfying science,” says Paul Kayne, head of Genomics (Discovery), Bristol-Myers Squibb (Princeton, NJ). And, by satisfying science, Kayne and Robert Nadon, Ph.D., associate professor, Department of Human Genetics at McGill University (Montreal, Quebec, Canada), mean productive and verifiable science that translates effectively to clinical applications.

May 28, 2018
The SLAS Community Struts Its Stuff!
The SLAS Community Struts Its Stuff!

By Sabeth Verpoorte, Ph.D.

Did you know that at one point earlier this month, SLAS had five active calls for abstracts in process (the 2019 SLAS International Conference and Exhibition, three additional events and one journal special issue), as well as the ongoing calls for manuscripts for SLAS Discovery and SLAS Technology? SLAS is a bustling community of practicing life sciences professionals who willingly share innovations for the betterment of all.

May 21, 2018
DNA-Encoded Library Technology: A Quarter Century of Progress
DNA-Encoded Library Technology: A Quarter Century of Progress

“DELT [DNA-Encoded Library Technology] provides an economical and feasible means to make progress toward the exploration of larger chemical spaces. Instead of a focusing on one to two million compounds in a typical high-throughput screen (HTS), a DELT library may present some hundred million compounds for selection by a biological target of interest. The concepts of drug-likeness, chemical diversity and compound collection are still important, but the efficiency of the DELT process shifts the balance of opportunity costs in a unique manner relative to the traditional HTS compound collection and process.” – Robert Goodnow, Ph.D., SLAS Discovery Guest Editor

May 14, 2018
Lineage Sequencing: A Novel Approach to Mutation Analysis
Lineage Sequencing: A Novel Approach to Mutation Analysis

“Biological processes are dynamic; they require dynamic measurements to understand them,” says Yehuda Brody, Ph.D. Brody, a third-year post-doctoral associate in the Blainey Lab at the Broad Institute of MIT and Harvard (Cambridge, MA) who has been visually measuring single cell gene expression kinetics for several years. Now, focusing on mutagenesis process kinetics, he and his colleagues have developed a new method for DNA sequencing that allow them to analyze the flow of mutation accumulation with single cell cycle resolution. Paul Blainey, Ph.D., presented this innovative approach at SLAS2018.

May 7, 2018
Mathias Uhlén: Discovering the Building Blocks of Man
Mathias Uhlén: Discovering the Building Blocks of Man

Researcher Mathias Uhlén, Ph.D., opens the human proteome for all researchers to explore. He then leads the journey into what makes us healthy, how disease starts, when the aging process begins and how to apply that knowledge to life sciences discovery and technology to improve the human condition.

April 30, 2018
An Exciting Time for the European SLAS Community
An Exciting Time for the European SLAS Community

By Sabeth Verpoorte, Ph.D.

Less than two months away, the 2018 SLAS Europe Conference and Exhibition promises to deliver! We’ve incorporated all we have learned about quality education and networking from the annual SLAS International Conference and Exhibition and added flavor of the region to offer this inaugural event June 27-29 at the spectacular Square Brussels Meeting Centre in Brussels, Belgium.

April 23, 2018
Digital PCR: Old Technology Brought to Life on a Novel Affordable Automated Platform
Digital PCR: Old Technology Brought to Life on a Novel Affordable Automated Platform

Paul Hung, Ph.D., started out as an electrical engineer, but halfway through his graduate studies at the University of California, Berkeley (UC Berkeley), he switched to bioengineering. “I was fascinated by how many unsolved problems and unlimited possibilities there were in biology and hoped that my engineering expertise could help,” Hung recalls. As a serial entrepreneur, and now the CEO of COMBiNATi, Hung saw “huge potential in field of genomics” and earned the 2018 SLAS Innovation Award for his presentation, “Microfluidic Siphoning Array: A Novel Scalable Digital PCR Integrated Platform.”

April 16, 2018
Unifying the Research Ecosystem: Solid Support Services for SLAS Journal Authors
Unifying the Research Ecosystem: Solid Support Services for SLAS Journal Authors

Attention current and prospective SLAS journal authors (which should be everybody reading this!): More than ever before, SLAS Discovery (Advancing Life Sciences R&D) and SLAS Technology (Translating Life Sciences Innovation) help authors by making the submission process faster and easier, boosting the global discoverability of published articles and enhancing recognition for authors and reviewers.

April 9, 2018
SLAS2018 Student Poster Competition Winners Swim Broader, Not Just Deeper
SLAS2018 Student Poster Competition Winners Swim Broader, Not Just Deeper

Chosen from a broad pool of innovative research, Xiao Wang, Ph.D., Sri Teja Mullapudi, M.Tech., and John Hickey, B.Sc., took top honors out of 50 undergraduate, graduate and post-doctoral students who participated in the SLAS2018 Student Poster Competition. The winners also seized opportunities to expand the audience for their research at this intersection of life sciences discovery and technology.

March 26, 2018
New Governance Model Empowers SLAS Volunteer Leadership
New Governance Model Empowers SLAS Volunteer Leadership

By Sabeth Verpoorte, Ph.D.

SLAS takes seriously its mission to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building. That’s a tall order, as it means that we need to continue to grow and change as a Society to be true to our mission. The SLAS governance structure must enable greater interaction and synergy between the SLAS Board of Directors and SLAS volunteer committees, and between committees themselves.

March 19, 2018
CRISPR Automated at the Bench: Microfluidics Enabling Innovation
CRISPR Automated at the Bench: Microfluidics Enabling Innovation

Hugo Sinha, a master’s student in the Department of Electrical and Computer Engineering at Concordia University in Montreal, Canada, is hoping to make automated CRISPR technology accessible to as many cancer researchers as possible. His vision is to “empower all cancer biologists to be able to program their gene editing experiments on their own benchtop instruments.” As one of the youngest presenters at SLAS2018 and an SLAS2018 Tony B. Academic Travel Award winner, Sinha presented his work in a podium presentation “Automating Gene Editing for Deciphering Cancer Pathways Using Microfluidics.”

March 12, 2018
Annika Jenmalm Jensen: Bigger Research Challenges Build Bigger Breakthroughs
Annika Jenmalm Jensen: Bigger Research Challenges Build Bigger Breakthroughs

She likes to solve complex research puzzles–those that require matching intellects, instruments and vast laboratory spaces spread across an entire country. She enjoys challenges that involve research reproducibility and those that introduce cutting edge technology. “This is the aspect of science I embrace–the challenges make research more intriguing.”

March 5, 2018
The People Powering the 2018 SLAS Technology Ten
The People Powering the 2018 <em>SLAS Technology</em> Ten

“We are pleased to recognize the innovators behind the 2018 SLAS Technology Ten,” says Edward Kai-Hua Chow, SLAS Technology editor-in-chief (National University of Singapore). “These hard-working individuals from Australia, China, Poland, Singapore, Spain, Switzerland, Taiwan and the United States had breakthroughs in micro-, nano- and digital technologies to improve drug delivery and therapy against a wide range of diseases, from wound healing to cancer. They report great advances in microfluidics, diagnostics, microtechnology, life sciences and biomedical assays and other technologies that are changing the way drugs are developed and evaluated to improve both efficacy and safety.”