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Editorial Archive

August 27, 2014
Flow Cytometry Powers High-Throughput Screening Advances

"We are all tasked with finding new drugs that can differentiate our companies and provide real benefit to patients," says John Joslin, research investigator at the Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA. "To do so, we need to establish biologically relevant screening assays for our high-throughput screening campaigns. However, increasing the biological relevance leads to more complex biology that requires new methodologies for lead identification and our screening systems must evolve to meet this challenge."

August 18, 2014
Lorenz Mayr: Listen to the Data

Early on in his scientific training, SLAS member Lorenz Mayr, Ph.D., learned to let the data speak for itself. Be precise about interpretation, but don't over-analyze. Most importantly he learned that it is never OK to be "about right" – you have to be absolutely right before you submit work for publication.

August 11, 2014
Eric Pei-Yu Chiou and Hideaki Tsutsui: Personal Notes from the JALA Guest Editor's Chair

Special issues published by the Journal of Biomolecular Screening (JBS) and the Journal of Laboratory Automation (JALA) represent hallmarks of important achievement by SLAS and its members, especially those whose sweat equity make them such meaningful and memorable successes. Two JALA guest editors share their recent experiences and demonstrate how personal passion fuels the SLAS Spirit of Community.

July 28, 2014
Cynthia Yin: Greeting a Bright Future in Science

Recent high school graduate Cynthia Yin is a well-rounded student who has a great mind for science, a gift for music and a mean game of golf. This class valedictorian excels in many areas of life and has a wall of awards to prove it, including an SLAS Tony B. Academic Travel Award. Her greatest accomplishment, however, is seeking opportunity and using it to advance her knowledge.

July 21, 2014
Drug Repurposing: Helping Companies Expand Treatment Options for Patients and Recoup Investments

Compared with trying to discover and develop a novel compound from scratch, repurposing an approved drug saves time and money. It might be for a different indication or to rescue a candidate drug that may have failed in early trials and developing it to treat a different condition. Repurposing also carries less risk to companies and to patients, according to SLAS Drug Repurposing SIG Co-chairs Roger Bosse, Ph.D., senior global product leader for PerkinElmer, Life Sciences & Technology and Mathieu Arcand, Ph.D., co-founder of Biopra.

June 30, 2014
Small Molecule Profiling: Dealing with the Data

"Although high-throughput screening has been going on for almost two decades, only now are substantial public datasets emerging and being made available for cross analysis—and they're large enough and well annotated enough to make a difference in our work," says Paul Clemons, Ph.D., director, Computational Chemical Biology Research at the Broad Institute.

June 23, 2014
Sumita Pennathur: Channels of Progress

Working in a channel that is 60,000 times smaller than a human hair, SLAS member Sumita Pennathur, Ph.D., is doing big work on a nano scale. Can she save the world moving one molecule at a time?

June 9, 2014
Rich Ellson: Adventures in a Brave New World

How does one seed a conservative science environment with new technology, particularly one that replaces a tool as basic as the lab coat? By being an active part of the community, listening to the challenges faced by its members and contributing to collaborative efforts.

June 2, 2014
Global Health: Putting Passion to Work with Novel Point-of-Care Diagnostics

"I'm passionate about global health, about my own research to develop technologies for use in resource-limited settings, as well as the work that others are doing to improve the lives of people in developing countries," says Peter Lillehoj, Ph.D., of Michigan State University in East Lansing. That passion motivated Lillehoj to serve as guest editor of a 2014 special issue of the Journal of Laboratory Automation (JALA) on New Developments in Global Health Technologies.

May 19, 2014
Develop Wise Skills to Achieve Career Goals

A recent Ph.D. has had three interviews in the last month. She shared that she heard back from her second most promising interview at a start-up company: "the people from HR just contacted me. They let me know that they have chosen another person."

May 5, 2014
3D Printing in the Lab: Facilitating Innovation, Fueling Visions

Two researchers who are working on projects with implications for different aspects of drug discovery reveal their motivations for using 3D printing in the laboratory. They are inspired not only by the challenge of doing innovative science, but also by the opportunity to make their work accessible to scientists around the world.

April 28, 2014
Settling a New Biotech Frontier

SLAS members Anne Marie Quinn and Thomas Hughes carved a place for their company, Montana Molecular, far from the biotech hubs that launched their careers. The company put down roots on Quinn's vision that the tools of science drive progress and the scientists who adopt those tools early have a professional advantage.

April 18, 2014
SLAS2014 Student Poster Winners Launch into Science

One small step: entering a poster contest. One giant leap: exposure to thousands of new contacts to advance research and accelerate careers.

March 31, 2014
Sample Management: Are You Paying Attention to All the Variables?

"Advances in precision medicine, outcomes management and genetic classification require high quality biospecimens, yet standard procedures for collecting, storing and handling such samples are lacking," says Katheryn Shea, vice president of Bioservices at Precision Bioservices in Frederick, MD, and immediate past president of the International Society for Biological and Environmental Repositories (ISBER), an SLAS strategic alliance partner. "Inconsistency in these processes can lead to inconsistent, irreproducible results," she warns.

March 24, 2014
SLAS Member Influences FIRST Experiences in Science

A sense of awe, a gasp or even five minutes of concentrated silence; these are the reactions SLAS member Jody Keck seeks as he works with elementary students to spark an early interest in science and technology. Even for the kids who don't grow up to be scientists, Keck hopes to plant a sense of curiosity and determination to find answers in the face of a challenge.

March 17, 2014
Researchers Advance Protein-Protein Interactions as Small Molecule Drug Targets

"There are very few targets that actually come all ready – born by nature – with small molecules bound to them for which you can analyze or form druggable sites. So, you need to develop other approaches to go after these challenging targets."
− James A. Wells, University of California, San Francisco

March 3, 2014
Stem Cell Technologies: 3D Culture is "Next Wave" for Drug Discovery

"The future of therapy is a molecule/cell therapy combination," says Sitta Sittampalam, Ph.D., senior scientific officer and project manager at the US National Institutes of Health (NIH)'s National Center for Advancing Translational Sciences, and co-chair of the SLAS Stem Cells and 3D Microtissues Special Interest Group. "In 20 years, if you have a failing kidney, you won't just get a pill and hope it works; you will receive an injection of stem cells and a drug that makes those stem cells go to your kidney to rebuild it."

February 24, 2014
Christine Brideau: An Early Adopter to Change

SLAS member Christine Brideau overcomes challenges in her career path by seizing the opportunities that travel along with them.

February 17, 2014
How Can You Get a Job? Meet Some People with Jobs!

Speed career coaching can be quite an experience. I enjoyed my two days in the SLAS2014 Member Center having 30-minute one-on-one meetings with scientists to talk about career planning. I was able to meet with around 15 different scientists at all stages of their careers. Now that I have had some time to think about the common themes that arose in our discussions, it is clear that a universal, key issue for those I met was that they just don't know many people with non-academic jobs.

January 27, 2014
Emilio Diez-Monedero: Laying the Groundwork

Emilio Diez-Monedero, Ph.D., has experienced more than 30 years of progress in the scientific community and heralds its continuing evolution. He eagerly anticipates serving as a member of the new SLAS Europe Council to expand the Society's value and impact across the continent.