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Special Issue

Personalized and Precision Medicine: Making N-of-1 Medicine a Reality

Dean Ho, Ph.D.
Professor of Oral Biology and Medicine, and Bioengineering
The Jane and Jerry Weintraub Center for Reconstructive Biotechnology
School of Dentistry and Henry Samueli School of Engineering and Applied Science
University of California, Los Angeles, CA  USA

Ali Zarrinpar, M.D., Ph.D.
Assistant Professor of Surgery
Division of Liver and Pancreas Transplantation
David Geffen School of Medicine
University of California, Los Angeles, CA  USA

 

The June 2017 issue of SLAS Technology (formerly the Journal of Laboratory Automation) presents a diligently peer-reviewed complement of 11 reviews and reports that explore innovation from a cross section of the disciplines driving major advances in clinical personalized and precision medicine.   

The issue reports new achievements in diagnostics and big data analytics and management, exclusion-based sample preparation, use of cell culture assays to predict drug resistance, use of automated flow cytometry to measure pharmacological profiles, multi-biomarker analysis for accurate tracking of treatment progression, and the application of metabolic pathway inhibitors to inspire new combination therapies.

Advances contributing to the foundation for the widespread implementation of personalized and precision medicine include a key breakthrough in exclusion-based sample preparation for individualized lung cancer data analytics and management; and a key breakthrough using a phenotypic personalized medicine technology platform that enables combination therapy in acute lymphoblastic leukemia to be optimized in a continuous fashion to markedly improve treatment outcomes. Optimized combination therapy and drug development are further highlighted in other engineering-based reports, and a perspective explores how successful approaches from the tech industry can be adopted to accelerate innovation in personalized and precision medicine by challenging conventional thinking.

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SLAS publishes two MEDLINE-indexed journals and accepts manuscripts on an ongoing basis from members and non-members.  > READ MORE

May 22, 2017