Society for Laboratory Automation and Screening: Medicinal Chemistry Facilities Directory

Medicinal Chemistry Facilities Directory

Vahlteich Medicinal Chemistry Core (VMCC)

Institution	University of Michigan
Contact Name	Scott Larsen, Research Professor of Medicinal Chemistry and Co-Director
Contact Email	sdlarsen@umich.edu
Main Website	Visit Main Website
Hit Selection and Optimization Services	- Hit Triage - Patent Analysis - Computational Filtering - Analog Synthesis - Structure-based Drug Design
Other Hit Selection and Optimization Services
Lead Selection and Optimization Services	- Custom-Designed Analog Synthesis - Solubility Assessment - Microsomal Stability Assessment - Permeability Assessment
Other Lead Selection and Optimization Services	computational tools, structure-based drug design, literature/patent searching
Scale-up Synthetic Capabilities for Hits/Analogs	10 g
Can the facility support in silico screening?	Yes
Is the facility open to projects not affiliated with host institution?	Yes
Is data collected in this facility publicly available?	Varies by project
Additional Comments	The VMCC is staffed entirely by scientists with pharmaceutical industry experience (over 100 collective years). Our core is dedicated to collaborating with biomedical investigators, advancing their research projects through a combination of the following: critical evaluation of screening hits, selection of lead compounds, design and synthesis of new analogs with greater potency and selectivity, improvement in drug-like properties (solubility, metabolic stability, cell permeability) and patent composition and filing. Specific expertise residing within, or available to, the core includes: computational tools (small molecule modeling, ligand-protein docking, pharmacophore generation), structure-based drug design, reaction substructure searching and literature/patent database searching. All of these provide the VMCC with the ability to drive projects rapidly and efficiently.