Ling Zhang of Tohoku University, Sendai, Japan
The image shows a large-scale and chemically stable SERS substrate for single molecule detection. Quasi-periodic wrinkles were made by introducing through thermal contraction of pre-strained polymer substrates. Plenty of nanogaps with various spacings as well as abundant nanotips and bowtie nanoantenna structures are obtained at the ridges of the wrinkles introduced by film shrinking. Our robust substrate that made by wrinkled nanoporous films contains a high number density of electromagnetic "hot spots" with a local SERS enhancement larger than 109.
Xianting Ding of University of California, Los Angeles, CA
A DMSO droplet containing highly concentrated JNK inhibitor SP600125 was added to water. The inhibitor nano-fibers are self-generated.
Thomas Hartmann of Newbury Park, CA
The image shows leaves of a water plant. The leaves are moving underwater in a creek in Denmark. It's more the art of life or nature.
Rakesh Karmacharya of The Broad Institute of Harvard and MIT, Cambridge, MA
These are neuronal cultures that were differentiated from induced pluripotent stem cell obtained by reprogramming human fibroblasts. The neuronal cultures are stained with the neuronal marker MAP2 and the synaptic protein Synapsin 1 with the corresponding color scheme:
Red: Neurons (MAP2) Green: Synaptic markers (Synapsin 1) Blue: Nuclei (DAPI)
We are generating human iPSC-derived neuronal cultures for image-based screening to indentify disease markers for schizophrenia and bipolar disorder.
Hanyoup Kim of Sandia National Laboratories, Livermore, CA
Color droplets on the digital microfluidic platform with the capillary interface.
Janos Kriston-Vizi of the Medical Research Council, London, UK
It shows a monolayer of HeLa cells imaged with a PerkinElmer Opera plate reader. A 3D stack was acquired then after 3D segmentation a blue isosurface mesh was generated, overlayed on the original, false color (red) voxel intensities.
Vindhya Kunduru of North Carolina State University, Raleigh, NC
CORN FIELDS: The golden corn fields in the horizon are an effect of salt crystallization after evaporation of PBS. The gold plates on the bottom and top sections of the image are gold microelectrodes. Natural image, no color enhancement.
George McNamara of University of Miami, Florida
Tiki_Goddess: Young mouse (~30 day old, ~40x14 mm)) trichrome stained tissue section showing many of the internal body parts. The uploaded image was scanned on a Meyer Instruments Pathscan slide scanner at 4000 dpi (~6.4 um pixel size).
Don Pottle of The Schepens Eye Research Institute, Boston, MA
A drop of commercial contact lens solution was allowed to dry and crystallize on a glass slide. This image was taken using a Nikon Eclipse E800 epifluorescent Microscope and SPOT digital camera. The magnification was 400x (40x oil immersion objective lens). Many interesting and varied crystals were observed. Among these, was this array looking like alien-like birds or moths flying over snow-capped mountain peaks, or possibly, over frosty evergreen tree branches.
Constantinos Zeinalipour of C. CySilicoTech Research Limited, Nicosia, Cyprus
It has been recognized a long time ago by parasitologists that parasitic relationships evolve into commensalistic and to mutualistic relationships due to selective pressure. In order to have the appearance of such symbiotic relationships it is evident that the parasites must damage the host as little as possible. Therefore, both changes in the parasite that make it less prompt to damage the host but also changes in the host that protect it from the parasite are favoured. In this abstract artwork we present the commensalistic relationship evolved from the symbiosis of "viruses" and a "cell culture". The structure of the cells is such that they generate cavities very similar to the shape of the cells in which the viruses try to enter. On one hand, the healthy cells are protected by certain colourful proteins that prohibit the viruses to transfer their genetic material into these cells. The healthy cells, on the other hand, emit nutrients into the cavities were the viruses reside so that the viruses can also survive within the cavities generated by the healthy cells.
Yi Zhang of Johns Hopkins University School of Medicine, Baltimore, MD
The image shows two types of quantum dots (QD) mixing in a 30ìL sessile droplet with the assistance of a micro magnetic gyromixer which spins on the surface of the sessile droplet. The micro gyromixer is designed to improve and mixing rate and automate the mixing process for droplet microfluidic platform. The photo is taken at the early stage of mixing. The green quantum dots (QDot 525) streamline and the orange quantum dots (QD605) streamline together develop into a heart-shaped sketch.