Yi Zhang and Cyrus Beh of Johns Hopkins University School of Medicine, Baltimore, MD (USA)
Five droplets of identical volume display gradually decreasing contact angles due to the surface energy gradient created on a polydimethylsiloxane (PDMS) substrate. Five water droplets were stained with different food dyes to aid visualization. The energy gradient is created by adjusting the surface roughness of the PDMS substrate through microengineering. Various regions on the PDMS substrate are roughened to different degrees by altering the sizes and spacing of the microstructures on the surface. The apparent contact angle ?a and the Young's intrinsic contact angle ?i are related to the surface roughness by Wenzel equation. cos?a = rcos?i, where r is the surface roughness defined as ratio of the true surface area over the planar areas.
Mark Bray of the Broad Institute, Cambridge MA (USA)
A cardiac myocyte (heart cell) is plated onto an extracellular matrix island which restricts its growth to the shape of the island (in this case, a triangle). The cell grows to fit the shape, and the cells are stained with three colors: cell nuclei are blue, actin proteins are green, and muscle proteins are red. The image was then tiled in Photoshop to create this pattern, reminiscent of holiday wrapping paper or stained glass.
Xianting Ding of the University of California, Los Angeles, CA (USA)
This SEM image was taken by accident when we were trying to visualized the AgI nanoparticles synthesized in our project. The AgI nanoparticles were resuspended in DI water. After about 1 minute, when the water evaporates, the nanoparticles self-organized into a beautiful whorl structure. The image looks like a volcano, but in "micro" size. When we zoomed into this volcano structure, the sizes of the nanoparticles display an extremely high uniformity. This image is a very good sample showing how the nature uses identical simple building blocks to create complex emerging structures.
Carolina Haass-Koffler of UCSF Ernest Gallo Clinic and Research Center, San Francisco, CA (USA)
Science, religion and art all strive for their own answers...but all are alike in awe of the mysteries of life.
Human cells transfected with a secreted binding protein (BP) and with GP-coupled receptors (GPCR). The synergistic interaction between protein and receptors fluorescence network, arises from cell body and extends out for cross-talk. On the background: The Creation of Adam, by Michelangelo, 1508-12, Sistine Chapel.
George Hanson of Life Technologies, Eugene, OR (USA)
Auto-fluorescent Spirogyra algae from pond water.
Lorena Kallal of GlaxoSmithKline, Collegeville, PA (USA)
Landscape created as a composite, combining parts from different immunofluorescent cellular images. The images include staining of nuclei (blue dots in 'water', and other cytoplasmic components of cells shown in green.
Anand Krishnan of Hotchkiss Brain Institute, Calgary, AB (CANADA)
Neuronal cell bodies are isolated from dorsal root ganglia of rats and cultured in vitro. Individual neurons are then immunostained for neurofilament expression to visualize neurite out growth from single neurons.
Jerry Shay of The University of Texas Southwestern Medical Center, Dallas, TX (USA)
Human Cell Mitochondria and Cytoskeleton: This image is an interphase human cell stained with DAPI for the DNA of the nucleus, red for mitochondria, and green for the actin cytoskeleton.
Manju Swaroop of NIH National Center for Advancing Translational Science TRND, Rockville, MD (USA)
Neurofilament image [differentiated neurons stained for the neuronal marker — neurofilament in green and nuclei in red].
Constantinos Zeinalipour-Yazdi of C. CySilicoTech Research Limited, Nicosia (CYPRUS)
Rapid progress in genome science have spurred observers to predict that biomedical research will be one of the foremost sciences of the 21st century. This is an exciting time for biomedical study and genomics research as their applications should generate innovative and powerful approaches to address a diverse array of biological and biomedical questions. It is our hope that humanity will use such discoveries to empower health practitioners in a fashion that leads to improved human health through the use of personalized medicine. The various colours and shapes in this abstract painting emphasize the importance of diversity in human's genome evolution.
Li Zhang of The Chinese University of Hong Kong, Shatin NT (HONG KONG)
Artistic rendering of a scanning electron micrograph showing an aggregation of nickel nanowires with several polystyrene microparticles around it. The nickel nanowires were synthesized by a template-assisted electroplating method, in which anodic aluminum oxide (AAO) membranes were applied as the templates. The microparticles have a diameter of approximate 6 micron.