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Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox

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Melanie Leveridge
Director
Screening, Profiling and Mechanistic Biology (UK)
GlaxoSmithKline
United Kingdom

Melanie Leveridge is director of GlaxoSmithKline’s (GSK’s) Screening Profiling and Mechanistic Biology UK team, within the global New Chemical Entity (NCE) molecular discovery organization. Leveridge has been with GSK since 2005 and in this time has held roles of increasing responsibility in a variety of small molecule discovery platform groups, leading teams to deliver high-throughput screening, lead optimization profiling, assay development and mechanistic biology studies. Leveridge also is passionate about technology and capability development, and has led numerous technology development collaborations particularly in the application of high-throughput mass spectrometry techniques for screening and compound profiling, a topic on which she has published a number of peer reviewed articles in SLAS journals. Leveridge also is an active member of the SLAS Americas Scientific Program Committee.

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Other SLAS Publications

Systematic Investigation of the Best Buffers for use in Screening by MALDI-Mass Spectrometry

The Evolution of MALDI-TOF Mass Spectrometry towards Ultra High-Throughput Screening: 1536 Well Format and Beyond

A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease using RapidFire Mass Spectrometry

Demonstrating Enhanced Throughput of RapidFire Mass Spectrometry through Multiplexing Using the JmjD2d Demethylase as a Model System

Lead Discovery for Microsomal Prostaglandin E Synthase Using a Combination of High-Throughput Fluorescent-Based Assays and RapidFire Mass Spectrometry

Configuration of a High-Content Imaging Platform for Hit Identification and Pharmacological Assessment of JMJD3 Demethylase Enzyme Inhibitors

Enabling Lead Discovery for Histone Lysine Demethylases by High-Throughput RapidFire Mass Spectrometry


SLAS publishes two PubMed:MEDLINE-indexed journals and accepts manuscripts on an ongoing basis from members and non-members.  > READ MORE

September 20, 2018