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2018

SLAS Welcomes Three New Members to the 2019 Board of Directors

SLAS Welcomes Three New Members to the 2019 Board of Directors

December 19, 2018

SLAS is pleased to announce the Board of Directors approved the slate of candidates for the 2019 Board of Directors at its November meeting. Each new board member will join the SLAS Board of Directors for three-year terms beginning at SLAS2019, February 2-6, in Washington, DC.

 

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

December 13, 2018

A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its suitability and reliability for application to early drug discovery campaigns.

 

Improved Fluorescence Methods for High-Throughput Protein Formulation Screening

Improved Fluorescence Methods for High-Throughput Protein Formulation Screening

November 28, 2018

A study in the December 2018 issue of SLAS Technology demonstrates the feasibility of using a steady-state/lifetime fluorescence plate reader for direct optimization of challenging formulation conditions and highlights the importance of performing formulation optimization under commercially relevant conditions.

 

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

November 26, 2018

Researchers from the University of Manchester (United Kingdom) explore recent developments and strategies for targeting the NLRP3 inflammasome as a potential therapeutic target in acute and chronic neurological and neurodegenerative diseases, and offer perspective on how this field may develop in the future.

 

SLAS Announces 50 Recipients of Tony B. Travel Award Program for SLAS2019

SLAS Announces 50 Recipients of Tony B. Travel Award Program for SLAS2019

November 1, 2018

SLAS, the Society for Laboratory Automation and Screening, has selected 50 students from 12 countries to present their research at SLAS2019 as the most recent winners of the SLAS Tony B. Academic Travel Award. These notable undergraduate students, graduate students, post-doctoral researchers and junior faculty members were selected by an independent panel of judges who evaluated their abstract proposals based on scientific merit and potential impact of the research toward the advancement of life sciences discovery and technology.

 

Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine

Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine

September 25, 2018

A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.

 

Advancing Life Sciences Research with the Internet of Things

Advancing Life Sciences Research with the Internet of Things

September 21, 2018

The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs.

 

Screening Strategies and Methods

Screening Strategies and Methods

September 10, 2018

A new review in SLAS Discovery explores how improved safety screening strategies and methods are improving the pharmaceutical discovery and development process. The authors outline several fundamental methods of the current drug screening processes and emerging techniques and technologies that promise to improve molecule selection. In addition, the authors discuss integrated screening strategies and provide examples of advanced screening paradigms.

 

SLAS Welcomes New Scientific Director

SLAS Welcomes New Scientific Director

August 6, 2018

Michael Tarselli, Ph.D., will join the Society for Laboratory Automation and Screening (SLAS) as its new Scientific Director, beginning September 1.

 

 

High-Throughput Flow Cytometry in Drug Discovery

High-Throughput Flow Cytometry in Drug Discovery

July 24, 2018

A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.

 

 

Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place

Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place

July 23, 2018

Technologies that are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells are showcased in the August 2018 special issue of SLAS Technology.

 

Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

July 17, 2018

A time-resolved fluorescence resonance energy transfer-based BTK occupancy assay measures target engagement in peripheral blood mononuclear cells (PBMCs) and in lymph-node and bone-marrow samples.

 

Platforms for Investigating LncRNA Functions

Platforms for Investigating LncRNA Functions

June 27, 2018

To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.

 

University of Kansas's Schilly Named Inaugural Recipient of 2018 SLAS Visiting Graduate Researcher Program Grant

University of Kansas's Schilly Named Inaugural Recipient of 2018 SLAS Visiting Graduate Researcher Program Grant

June 22, 2018

SLAS has selected Kelci Schilly, a graduate research assistant in the Department of Chemistry at the University of Kansas (Lawrence, KS, USA), as the inaugural recipient of the 2018 SLAS Visiting Graduate Researcher Grant, and will cover her three-month visit to the laboratory of SLAS President Sabeth Verpoorte, Ph.D., at the University of Groningen (The Netherlands).

 

Using Fragment-Based Approaches to Discover New Antibiotics

Using Fragment-Based Approaches to Discover New Antibiotics

June 21, 2018

A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.

 

Integrated Lead Discovery: An Evolving Toolbox

Integrated Lead Discovery: An Evolving Toolbox

June 15, 2018

A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

 

A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues

A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues

June 13, 2018

New research describes the development of a novel screening platform with automated production of 3D muscle- and tendon-like tissues using 3D bioprinting.

 

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

June 5, 2018

Researchers at Coyne Scientific (Atlanta, GA) share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.

 

 

The Evolution in Flow Cytometry: Turning a Low-Throughput Platform into an Automated High-Throughput System

The Evolution in Flow Cytometry: Turning a Low-Throughput Platform into an Automated High-Throughput System

May 30, 2018

New research highlights a diversity of approaches that automated high-throughput flow cytometry has enabled for phenotypic drug discovery.

 

Quantitative Imaging in Life Sciences and Biomedical Research

Quantitative Imaging in Life Sciences and Biomedical Research

May 23, 2018

The June 2018 special issue of SLAS Technology provides a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.

 

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2017

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of Cytochrome CYP1A2 Inhibitors in Metabolic Mixtures

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of Cytochrome CYP1A2 Inhibitors in Metabolic Mixtures

December 21, 2017

This new (and freely available) original research article presents a fast, robust and accurate methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures. The methodology is centered around an at-line nanofractionation platform in which a metabolic mixture is chromatographically separated followed by parallel on-line mass spectrometric (MS) analysis and at-line nanofractionation on high-density microtiter well plates that are then directly exposed to a bioassay.

 

A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents  Targeting Fructose-1,6-Bisphosphate Aldolase

A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase

December 21, 2017

An original research report by Eun Jeong Cho et al. (University of Texas at Austin) in the January 2018 Issue of SLAS Discovery presents a newly designed biochemical assay that is rapid, sensitive, inexpensive, and high-throughput screening (HTS)-friendly to identify antagonist against aldolase A (ALDOA). 

 

 

Bioluminescent Succinate Detection for Monitoring the Activity of Dioxygenases and JMJC Demethylases

Bioluminescent Succinate Detection for Monitoring the Activity of Dioxygenases and JMJC Demethylases

December 14, 2017

A new methodology enables the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily.

 

 

Advances in MALDI Mass Spectrometry within Drug Discovery

Advances in MALDI Mass Spectrometry within Drug Discovery

November 28, 2017

SLAS Discovery marks the 30th anniversary of Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI TOF), the soft ionization technique for analyzing non-volatile biomolecules using mass spectrometry, with a special issue showcasing 10 new research reports.

 

 

Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing

Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing

November 22, 2017

A review article in the December 2017 issue of SLAS Technology provides important information for life sciences and technology professionals in academia and industry and members of the general public who are interested in antibiotic resistance, general microbial detection principles, in vitro diagnostics, micro- and nanotechnologies, and next generation rapid microbial testing methods.

 

Theranostic Nanoparticles for Tracking and Monitoring Disease State

Theranostic Nanoparticles for Tracking and Monitoring Disease State

November 9, 2017

A new SLAS Technology review article by researchers at the University of Southern California and the University of California, Los Angeles, sheds light on the growing number and more sophisticated designs of theranostic nanoparticles.

 

 

Three New Members Elected to SLAS Board of Directors

Three New Members Elected to SLAS Board of Directors

November 9, 2017

SLAS is pleased to announce the addition of Emilio Diez Monedero, Peter Brian Simpson and Severine Tamas-Lhoustau to the Society's Board of Directors. They begin three-year terms in February 2018.

 

 

In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization

In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization

November 1, 2017

A new SLAS Discovery article available for free ahead-of-print enables researchers to derive more clinically-relevant information from 3D cell culture models.

 

 

New Approaches to Difficult Drug Targets: The Phosphatase Story

New Approaches to Difficult Drug Targets: The Phosphatase Story

September 28, 2017

Discovering new drugs has never been easy and some potential drug targets have historically been viewed as too challenging and thus off limits for prosecution. In a new SLAS Discovery review, authors John S. Lazo et al. of the University of Virginia reflect on the nature of protein tyrosine phosphatases and explores reasons why these enzymes have been eschewed by drug hunters, and how the landscape is beginning to change.

 

Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment

Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment

September 25, 2017

A new report shows how microsystems can be used to understand processes in heart tissue in detail and to test newly developed compounds applied in the treatment of cardiac diseases.

 

New Therapeutic Targets for Osteoarthritis Pain

New Therapeutic Targets for Osteoarthritis Pain

August 25, 2017

An exploration of the latest understanding of the complex mechanisms behind OA pain offers new possibilities and potential treatment targets for osteoarthritis (OA) pain. New areas of research discussed include the use of combination therapies and the development of biomarkers to target effective pain treatment.

 

Micro- and Nanotechnologies for Quantitative Biology and Medicine

Micro- and Nanotechnologies for Quantitative Biology and Medicine

July 21, 2017

The August 2017 issue of SLAS Technology (formerly the Journal of Laboratory Automation) showcases 10 new reviews and original research reports that illustrate how the progression of research assays from qualitative outputs toward increasingly sensitive quantitative outputs is transforming life sciences and biomedical research and diagnostics by improving the ability of researchers and clinicians to detect and quantify increasingly complex assays.

 

Control of the Unfolded Protein Response in Health and Disease

Control of the Unfolded Protein Response in Health and Disease

July 19, 2017

Information generated by screening tools, readily available therapies and potential pathways to drug development are the cornerstone of informed clinical research and clinical trial design. In a new review in the August 2017 issue of SLAS Discovery (formerly the Journal of Biomolecular Screening), authors Eric Chevet, Ph.D., of Inserm U1242 (Rennes, France) et al. analyze the recent literature and review the impact of unfolded protein response (UPR) in health and disease.

 

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