A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.
The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs.
A new review in SLAS Discovery explores how improved safety screening strategies and methods are improving the pharmaceutical discovery and development process. The authors outline several fundamental methods of the current drug screening processes and emerging techniques and technologies that promise to improve molecule selection. In addition, the authors discuss integrated screening strategies and provide examples of advanced screening paradigms.
Michael Tarselli, Ph.D., will join the Society for Laboratory Automation and Screening (SLAS) as its new Scientific Director, beginning September 1.
A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.
Technologies that are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells are showcased in the August 2018 special issue of SLAS Technology.
A time-resolved fluorescence resonance energy transfer-based BTK occupancy assay measures target engagement in peripheral blood mononuclear cells (PBMCs) and in lymph-node and bone-marrow samples.
To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.
SLAS has selected Kelci Schilly, a graduate research assistant in the Department of Chemistry at the University of Kansas (Lawrence, KS, USA), as the inaugural recipient of the 2018 SLAS Visiting Graduate Researcher Grant, and will cover her three-month visit to the laboratory of SLAS President Sabeth Verpoorte, Ph.D., at the University of Groningen (The Netherlands).
A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.
A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.
New research describes the development of a novel screening platform with automated production of 3D muscle- and tendon-like tissues using 3D bioprinting.
Researchers at Coyne Scientific (Atlanta, GA) share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.
New research highlights a diversity of approaches that automated high-throughput flow cytometry has enabled for phenotypic drug discovery.
The June 2018 special issue of SLAS Technology provides a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.
The June issue of SLAS Discovery features two special collections of articles that address important trends for the advancement of life sciences R&D. Both collections include robust editorials by the guest editors, offering informed thoughts about the challenges and opportunities presented by these influential topics.
This vision of simplifying disease diagnosis using topically-applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.
In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife (“LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”) explain their general views on their novel discoveries and discuss ideas on the relevant new questions generated by their data.
A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for free.
Santosh Paidi, a graduate research assistant in the Department of Mechanical Engineering and at Johns Hopkins University, has been selected as the 2018 recipient of the SLAS Graduate Education Fellowship Grant. The $100,000 SLAS fellowship grant, awarded over two years, allows Paidi to continue his work in the lab of Ishan Barman, Ph.D., which employs vibrational spectroscopy and recent improvements in areas such as optics, nanotechnology and computing, to develop improved diagnostic tools that can provide rapid, robust, quantitative and molecular-specific readouts from biological specimen.
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