A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.
A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.
New research describes the development of a novel screening platform with automated production of 3D muscle- and tendon-like tissues using 3D bioprinting.
Researchers at Coyne Scientific (Atlanta, GA) share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.
New research highlights a diversity of approaches that automated high-throughput flow cytometry has enabled for phenotypic drug discovery.
The June 2018 special issue of SLAS Technology provides a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.
The June issue of SLAS Discovery features two special collections of articles that address important trends for the advancement of life sciences R&D. Both collections include robust editorials by the guest editors, offering informed thoughts about the challenges and opportunities presented by these influential topics.
This vision of simplifying disease diagnosis using topically-applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.
In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife (“LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”) explain their general views on their novel discoveries and discuss ideas on the relevant new questions generated by their data.
A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for free.
Santosh Paidi, a graduate research assistant in the Department of Mechanical Engineering and at Johns Hopkins University, has been selected as the 2018 recipient of the SLAS Graduate Education Fellowship Grant. The $100,000 SLAS fellowship grant, awarded over two years, allows Paidi to continue his work in the lab of Ishan Barman, Ph.D., which employs vibrational spectroscopy and recent improvements in areas such as optics, nanotechnology and computing, to develop improved diagnostic tools that can provide rapid, robust, quantitative and molecular-specific readouts from biological specimen.
A new original research report available ahead-of-print at SLAS Technology demonstrates the semi-automation of a GlycoWorks RapiFluor-MS (RFMS) Kit using a pipetting robot to improve life sciences research productivity.
In the April 2018 issue of SLAS Technology, Breitwieser and colleagues of the Karlsruhe Institute of Technology (Germany) describe a fully automated high-throughput sorting system for zebrafish embryo phenotypes that benefits high-throughput screening by saving time and improving accuracy.
A review article by Prof. Stefan Broer, Ph.D., highlights opportunities and challenges in using amino acid transporters as drug targets. Amino Acid Transporters as Disease Modifiers and Drug Targets provides an overview of methods used to identify new inhibitors for amino acid transporters and outlines cell and organ function where these can be used to modulate, prevent or to treat diseases.
A perspective article in the March 2018 issue of SLAS Discovery from the biology group at the European Screening Centre Newhouse details how the European Lead Factory (ELF), a large publicly accessible drug discovery platform, uses microscale thermophoresis (MST) to aid in the prioritization of small molecule hits from high-throughput screening.
SLAS Discovery (formerly the Journal of Biomolecular Screening) and SLAS Technology (formerly the Journal of Laboratory Automation), both published by SLAS (Society of Laboratory Automation and Screening) in partnership with SAGE Publishing, hosted a special reception to celebrate the 2018 SLAS Journal Achievement Award honorees on Feb. 6 at SLAS2018, the SLAS International Conference and Exhibition, held Feb. 3-7, 2018, in San Diego, CA.
Three organizations earned a SLAS New Product Award yesterday at SLAS2018 in San Diego for their innovative new productsthat have played an important role in the advancement of life sciences drug discovery and development.
SLAS2018 was all about science and innovation as new keynote lectures, cutting-edge podium presentations and the new SLAS Ignite Theater series stoked the collaborative nature of today's life sciences professionals with three days of ground-breaking presentations that left attendees pondering new ways to keep pace with the speed of science.
A phenotypic high-throughput screen to identify modulators that improve mutant cystic fibrosis transmembrane conductance regulator (CFTR) activity is described in the SLAS Discovery February 2018 front cover feature article by Giuliano and colleagues of Proteostasis Therapeutics, Inc. (Cambridge, MA).
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