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2018

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

December 13, 2018

A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its suitability and reliability for application to early drug discovery campaigns.

 

Improved Fluorescence Methods for High-Throughput Protein Formulation Screening

Improved Fluorescence Methods for High-Throughput Protein Formulation Screening

November 28, 2018

A study in the December 2018 issue of SLAS Technology demonstrates the feasibility of using a steady-state/lifetime fluorescence plate reader for direct optimization of challenging formulation conditions and highlights the importance of performing formulation optimization under commercially relevant conditions.

 

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

November 26, 2018

Researchers from the University of Manchester (United Kingdom) explore recent developments and strategies for targeting the NLRP3 inflammasome as a potential therapeutic target in acute and chronic neurological and neurodegenerative diseases, and offer perspective on how this field may develop in the future.

 

SLAS Announces 50 Recipients of Tony B. Travel Award Program for SLAS2019

SLAS Announces 50 Recipients of Tony B. Travel Award Program for SLAS2019

November 1, 2018

SLAS, the Society for Laboratory Automation and Screening, has selected 50 students from 12 countries to present their research at SLAS2019 as the most recent winners of the SLAS Tony B. Academic Travel Award. These notable undergraduate students, graduate students, post-doctoral researchers and junior faculty members were selected by an independent panel of judges who evaluated their abstract proposals based on scientific merit and potential impact of the research toward the advancement of life sciences discovery and technology.

 

Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine

Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine

September 25, 2018

A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.

 

Advancing Life Sciences Research with the Internet of Things

Advancing Life Sciences Research with the Internet of Things

September 21, 2018

The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs.

 

Screening Strategies and Methods

Screening Strategies and Methods

September 10, 2018

A new review in SLAS Discovery explores how improved safety screening strategies and methods are improving the pharmaceutical discovery and development process. The authors outline several fundamental methods of the current drug screening processes and emerging techniques and technologies that promise to improve molecule selection. In addition, the authors discuss integrated screening strategies and provide examples of advanced screening paradigms.

 

SLAS Welcomes New Scientific Director

SLAS Welcomes New Scientific Director

August 6, 2018

Michael Tarselli, Ph.D., will join the Society for Laboratory Automation and Screening (SLAS) as its new Scientific Director, beginning September 1.

 

 

High-Throughput Flow Cytometry in Drug Discovery

High-Throughput Flow Cytometry in Drug Discovery

July 24, 2018

A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.

 

 

Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place

Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place

July 23, 2018

Technologies that are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells are showcased in the August 2018 special issue of SLAS Technology.

 

Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

July 17, 2018

A time-resolved fluorescence resonance energy transfer-based BTK occupancy assay measures target engagement in peripheral blood mononuclear cells (PBMCs) and in lymph-node and bone-marrow samples.

 

Platforms for Investigating LncRNA Functions

Platforms for Investigating LncRNA Functions

June 27, 2018

To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.

 

University of Kansas's Schilly Named Inaugural Recipient of 2018 SLAS Visiting Graduate Researcher Program Grant

University of Kansas's Schilly Named Inaugural Recipient of 2018 SLAS Visiting Graduate Researcher Program Grant

June 22, 2018

SLAS has selected Kelci Schilly, a graduate research assistant in the Department of Chemistry at the University of Kansas (Lawrence, KS, USA), as the inaugural recipient of the 2018 SLAS Visiting Graduate Researcher Grant, and will cover her three-month visit to the laboratory of SLAS President Sabeth Verpoorte, Ph.D., at the University of Groningen (The Netherlands).

 

Using Fragment-Based Approaches to Discover New Antibiotics

Using Fragment-Based Approaches to Discover New Antibiotics

June 21, 2018

A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.

 

Integrated Lead Discovery: An Evolving Toolbox

Integrated Lead Discovery: An Evolving Toolbox

June 15, 2018

A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

 

A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues

A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues

June 13, 2018

New research describes the development of a novel screening platform with automated production of 3D muscle- and tendon-like tissues using 3D bioprinting.

 

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

June 5, 2018

Researchers at Coyne Scientific (Atlanta, GA) share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.

 

 

The Evolution in Flow Cytometry: Turning a Low-Throughput Platform into an Automated High-Throughput System

The Evolution in Flow Cytometry: Turning a Low-Throughput Platform into an Automated High-Throughput System

May 30, 2018

New research highlights a diversity of approaches that automated high-throughput flow cytometry has enabled for phenotypic drug discovery.

 

Quantitative Imaging in Life Sciences and Biomedical Research

Quantitative Imaging in Life Sciences and Biomedical Research

May 23, 2018

The June 2018 special issue of SLAS Technology provides a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.

 

Two New <em>SLAS Discovery</em> Special Collections Now Online: DNA-Encoded Chemical Library Technologies and Statistical Applications in Knowledge and Drug Discovery

Two New SLAS Discovery Special Collections Now Online: DNA-Encoded Chemical Library Technologies and Statistical Applications in Knowledge and Drug Discovery

May 22, 2018

The June issue of SLAS Discovery features two special collections of articles that address important trends for the advancement of life sciences R&D. Both collections include robust editorials by the guest editors, offering informed thoughts about the challenges and opportunities presented by these influential topics.

 

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Jill Hronek, Director of Marketing Communications
Telephone: +1.630.256.7527, ext. 103
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