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2018

SLAS Welcomes New Scientific Director

SLAS Welcomes New Scientific Director

August 6, 2018

Michael Tarselli, Ph.D., will join the Society for Laboratory Automation and Screening (SLAS) as its new Scientific Director, beginning September 1.

 

 

High-Throughput Flow Cytometry in Drug Discovery

High-Throughput Flow Cytometry in Drug Discovery

July 24, 2018

A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.

 

 

Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place

Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place

July 23, 2018

Technologies that are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells are showcased in the August 2018 special issue of SLAS Technology.

 

Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

July 17, 2018

A time-resolved fluorescence resonance energy transfer-based BTK occupancy assay measures target engagement in peripheral blood mononuclear cells (PBMCs) and in lymph-node and bone-marrow samples.

 

Platforms for Investigating LncRNA Functions

Platforms for Investigating LncRNA Functions

June 27, 2018

To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.

 

University of Kansas's Schilly Named Inaugural Recipient of 2018 SLAS Visiting Graduate Researcher Program Grant

University of Kansas's Schilly Named Inaugural Recipient of 2018 SLAS Visiting Graduate Researcher Program Grant

June 22, 2018

SLAS has selected Kelci Schilly, a graduate research assistant in the Department of Chemistry at the University of Kansas (Lawrence, KS, USA), as the inaugural recipient of the 2018 SLAS Visiting Graduate Researcher Grant, and will cover her three-month visit to the laboratory of SLAS President Sabeth Verpoorte, Ph.D., at the University of Groningen (The Netherlands).

 

Using Fragment-Based Approaches to Discover New Antibiotics

Using Fragment-Based Approaches to Discover New Antibiotics

June 21, 2018

A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.

 

Integrated Lead Discovery: An Evolving Toolbox

Integrated Lead Discovery: An Evolving Toolbox

June 15, 2018

A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

 

A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues

A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues

June 13, 2018

New research describes the development of a novel screening platform with automated production of 3D muscle- and tendon-like tissues using 3D bioprinting.

 

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

June 5, 2018

Researchers at Coyne Scientific (Atlanta, GA) share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.

 

 

The Evolution in Flow Cytometry: Turning a Low-Throughput Platform into an Automated High-Throughput System

The Evolution in Flow Cytometry: Turning a Low-Throughput Platform into an Automated High-Throughput System

May 30, 2018

New research highlights a diversity of approaches that automated high-throughput flow cytometry has enabled for phenotypic drug discovery.

 

Quantitative Imaging in Life Sciences and Biomedical Research

Quantitative Imaging in Life Sciences and Biomedical Research

May 23, 2018

The June 2018 special issue of SLAS Technology provides a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.

 

Two New <em>SLAS Discovery</em> Special Collections Now Online: DNA-Encoded Chemical Library Technologies and Statistical Applications in Knowledge and Drug Discovery

Two New SLAS Discovery Special Collections Now Online: DNA-Encoded Chemical Library Technologies and Statistical Applications in Knowledge and Drug Discovery

May 22, 2018

The June issue of SLAS Discovery features two special collections of articles that address important trends for the advancement of life sciences R&D. Both collections include robust editorials by the guest editors, offering informed thoughts about the challenges and opportunities presented by these influential topics.

 

Simplifying Skin Disease Diagnosis with Topical Nanotechnology

Simplifying Skin Disease Diagnosis with Topical Nanotechnology

May 18, 2018

This vision of simplifying disease diagnosis using topically-applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.

 

 

New <em>SLAS Discovery</em> Auto-Commentary by the Authors of

New SLAS Discovery Auto-Commentary by the Authors of "LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle"

May 4, 2018

In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife (“LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”) explain their general views on their novel discoveries and discuss ideas on the relevant new questions generated by their data.

 

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

April 20, 2018

A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for free.

 

Johns Hopkins University's Paidi Named 2018 Recipient of SLAS Graduate Education Fellowship Grant

Johns Hopkins University's Paidi Named 2018 Recipient of SLAS Graduate Education Fellowship Grant

April 10, 2018

Santosh Paidi, a graduate research assistant in the Department of Mechanical Engineering and at Johns Hopkins University, has been selected as the 2018 recipient of the SLAS Graduate Education Fellowship Grant. The $100,000 SLAS fellowship grant, awarded over two years, allows Paidi to continue his work in the lab of Ishan Barman, Ph.D., which employs vibrational spectroscopy and recent improvements in areas such as optics, nanotechnology and computing, to develop improved diagnostic tools that can provide rapid, robust, quantitative and molecular-specific readouts from biological specimen.

 

Automated Preparation of MS-Sensitive Fluorescently-Labeled N-Glycans with a Commercial Pipetting Robot

Automated Preparation of MS-Sensitive Fluorescently-Labeled N-Glycans with a Commercial Pipetting Robot

April 5, 2018

A new original research report available ahead-of-print at SLAS Technology demonstrates the semi-automation of a GlycoWorks RapiFluor-MS (RFMS) Kit using a pipetting robot to improve life sciences research productivity.

 

Fully Automated Pipetting Sorting System for Different Morphological Phenotypes of Zebrafish Embryos

Fully Automated Pipetting Sorting System for Different Morphological Phenotypes of Zebrafish Embryos

March 22, 2018

In the April 2018 issue of SLAS Technology, Breitwieser and colleagues of the Karlsruhe Institute of Technology (Germany) describe a fully automated high-throughput sorting system for zebrafish embryo phenotypes that benefits high-throughput screening by saving time and improving accuracy.

 

Protein Nutrition for Cells and Organisms: Can We Use it to Treat Diseases?

Protein Nutrition for Cells and Organisms: Can We Use it to Treat Diseases?

March 21, 2018

A review article by Prof. Stefan Broer, Ph.D., highlights opportunities and challenges in using amino acid transporters as drug targets. Amino Acid Transporters as Disease Modifiers and Drug Targets provides an overview of methods used to identify new inhibitors for amino acid transporters and outlines cell and organ function where these can be used to modulate, prevent or to treat diseases.

 

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