This full-day workshop will cover a broad range of critical concepts underlying assay development and implementation for high-throughput screening (HTS) and lead discovery projects. Many of the instructors have 20 to 30 years of experience in the field of drug discovery and will share information not readily found in a classroom or published material outside of the Assay Guidance Manual.
Who Should Attend?
- Individuals involved in bioassay development for drug discovery and development
- Academic, industrial and government laboratory scientists who are planning or beginning to develop test methods for high- or low-throughput screening that are amenable to automation using appropriate statistical and operational concepts
- Early-career researchers and experienced investigators who wish to learn about the latest assay concepts for HTS and lead optimization
- Learn best practices for the development and implementation of robust assays.
- Improve research projects involving drug discovery and know where to find further information.
- Identify reagents, methods and instrumentation that are well suited to robust assays.
- Acquire the skills to be able to develop robust assays and counter assays for new targets.
- Seek practical advice about individual research challenges.
- Gain an overview of the Assay Guidance Manual e-book as an important resource for detailed information about robust assay methods and best practices in quantitative biology.
- Learn practical approaches for developing robust assays for biochemical, cell-based and high-content screening as well as the selection and development of optimal assay reagents.
- Identify and develop optimal assay reagents and optimal assay instrumentation.
- Discuss and interpret important statistical and data analysis concepts with an emphasis on using these concepts to collect the best possible data and make go/no go decisions based on experimental results.
- Gain an overview of lead selection and optimization by medicinal chemistry.
- Dissect case studies on how to build translatable biochemical and cell-based assays for drug development.
- Share experiences and seek practical advice about individual research concerns.