For Immediate Release
Oak Brook, IL (August 31, 2021) – The September edition of SLAS Discovery is a Special Collection featuring the cover article, “Applications of Biophysics in Early Drug Discovery” by Geoffrey A. Holdgate (AstraZeneca, Macclesfield, UK) and Christian Bergsdorf, Ph.D. (Novartis Institutes for Biomedical Research, Basel, Switzerland).
This special collection seeks to illustrate the existing and developing use of biophysical methods in the identification and characterization of molecules in early drug discovery. Many of these methods can be applied to understand the binding interactions of target proteins with small molecules as well as peptides, proteins, antibodies, sugars, and nucleic acids. This issue highlights the adaptation of existing and developing technologies that have successfully identified or characterized hits including graphene bioelectronic sensing technology, the application of thermal shift assays to screen compounds, fluorescence-based methods and light utilization.
Mass spectrometry (MS) facilitates fast target enablement in drug discovery via label-free quantification of relevant analytes and until recently did not meet the time efficiency standards of established optical methods. In the article “Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery" by Roman P. Simon, et al., the authors describe the establishment of fully automated ADE-OPI-MS, enabled by the recently commercialized Echo-MS (Sciex) device as an in-line readout strategy for HTS. In the context of the model target cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), the authors present the identification and optimization of critical ADE-OPI-MS method parameters to enable sub-second assessment of enzymatic activity directly from incubation mixtures in 1536-well format. The article describes the integration of this innovative readout technology into a fully automated assay platform to enable the unattended assessment of small molecule-mediated enzyme inhibition at HTS-capable throughput.
This issue of SLAS Discovery also includes three articles of original research:
Other articles in the Special Collection include:
Access to September’s SLAS Discovery issue is available at https://journals.sagepub.com/toc/jbxb/current. For more information about SLAS and its journals, visit https://www.slas.org/publications/slas-discovery/.
SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.
SLAS Discovery: Advancing the Science of Drug Discovery, 2019 Impact Factor 2.918. Editor-in-Chief Robert M. Campbell, Ph.D., Twentyeight-Seven Therapeutics, Boston, MA (USA).
SLAS Technology: Translating Life Sciences Innovation, 2019 Impact Factor 3.047. Editor-in-Chief Edward Kai-Hua Chow, Ph.D., National University of Singapore (Singapore).
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